Last I checked, Seamless Mode in VirtualBox was buggy, and really annoying to use. I’ve recently switched to my Macbook full-time (My big Windows Machine stays plugged into the LAN and is able to be remotely turned on via LogMeIn in case I need it), which means that I’m good for most things, but certain items on Windows are still essential. One great program is WIndows Live Writer, which I haven’t found a free Mac counterpart. Recently I figured I’d try installing it in my Win7 Virtualbox machine, and then try out Seamless mode. The result is the following screenshot:
You’ll notice that’s an IE window, a Live Writer screen (With this post) and a Windows Taskbar on the bottom of the screen above OS X’s Dock.
When I last played with Seamless Mode, on a WIn XP Virtual Machine a year or so ago, it had a lot of issues with rendering properly (artifacting, etc..), however I haven’t had that with Seamless on Win 7 & VirtualBox 4.0. Nice setup for those of us not committed to one platform 
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